We ate here the day after Christmas 2009 for lunch. HUGE portions of food. Crackers with delicious garlic butter. Salad was so-so. My husband said the mullet was perfection; brother in law loved the crab cakes; sister loved the boiled shrimp; I enjoyed the fried oysters, but 'ware the menu's small print about broiled seafood - it comes covered in onions and parsley. I sent my scallops back and had the toppings removed. There's a great selection of food, but the prices are HIGH. Seafood usually is, but I expected a smaller, more reasonable lunch portion. The key lime pie (to go) was EXCELLENT. Service was adequate and ambience was okay. Lots of locals there. We went to Panacea specifically for Angelo's. I don't know that I'd drive nearly 3 hours to eat there again. It wasn't THAT great.